Insulin resistance or glucose intolerance appears to be not related to the pathological characteristics of Alzheimer disease (AD). That is according to the JAMA Neurology in a report they recently published online. In the same report, insulin resistance or glucose intolerance have not been shown to be associated to the accumulation of β-amyloid (Αβ) in the body. Αβ is a protein that can be found in the brain. (http://www.sciencedaily.com/releases/2013/07/130729231715.htm)
This suggests that a person who is diabetic may not be at risk of developing AD. However, researchers headed by Madhav Thambisetty, MD, PhD said that further research is needed to determine whether symptoms of cognitive impairments associated with diabetes are facilitated by pathological features that are associated with AD. Long-term studies are needed to establish the relationship between insulin, diabetes mellitus and Alzheimer’s disease.
Although their findings are not conclusive, the team said that it is unlikely that glucose intolerance and/or insulin resistance and AD pathology are related. The research data suggests that insulin resistance and/or glucose intolerance seems to have nothing to do with the pathogenesis of Alzheimer’s disease.
The results are corroborated by another study conducted by Dr. Richard O’Brien and his colleagues from the John Hopkins University School of Medicine. The results of their study were also published in JAMA Neurology, the July 29, 2013 edition.